沈錫輝，西北農林科技大學生命科學學院教授、博導，國家杰出青年科學基金獲得者，入選國家“萬人計劃”、科技部中青年科技創新領軍人才推進計劃和陜西省特支計劃，旱區作物逆境生物學國家重點實驗室學術骨干，“農業與環境微生物學研究團隊”學術帶頭人，西北農林科技大學“青年英才培養計劃”首屆入選者。 

長期從事農業與環境微生物領域的前沿研究，在細菌六型分泌系統的離子轉運與抗宿主天然免疫新功能研究、微生物-宿主-環境相互作用機制與調控研究、耐藥菌防控新策略研究、污染物降解與生物修復、植物內共生微生物促作物抗旱抗逆機制研究等方面取得了比較突出的進展，以通訊作者在Nature Communications、PNAS、Cell Reports、PLoS Pathogens、mBio等國際著名期刊發表SCI論文50余篇。獲授權專利6件。曾作為主要研究人員參加國家重大專項，973，863, 國家自然科學基金等項目的研究。 多次應邀在國際、國內學術會議做大會報告及分會場主旨報告。

教育及工作經歷：

1994年獲西北農業大學（現西北農林科技大學）農學系農學專業，學士學位。

1994-09至1997-06，西北農業大學基礎科學系生化專業，碩士學位。

2001-09至2005-07，中國科學院微生物研究所，微生物學博士學位。

2005-07至2008-06，美國普度大學生物科學系， 細胞微生物，博士后。

1997-07至2001-08，湖北省Bt研究開發中心 科研部, 助理研究員

2008-06至2010-06，中科院武漢病毒所病毒學國家重點實驗室副研究員。

2010-07至現在，西北農林科技大學生命科學學院教授、博導。 

學術兼職： 

1、兼任陜西省農業與環境微生物重點實驗室副主任。

2、中國微生物學會普通微生物專業委員會委員。

3、中國遺傳學會微生物遺傳專業委員會委員。

4、中國農業生物技術學會微生物生物技術分會理事。

5、陜西省微生物協會理事。

6、國際期刊《Frontiers in Cellular and Infection Microbiology》 Associate Editor，《Applied and Environmental Microbiology》編委等。 

 

研究方向：

主要從事農業與環境微生物學研究，在細菌六型分泌系統的功能研究及效應蛋白鑒定、細菌生物膜形成及運動性調控、植物內共生微生物組及其對農作物的促生抗旱功能研究、芳香化合物降解機制等方面取得了比較突出的成績， 包括 1）首次發現細菌六型分泌系統的離子轉運功能，率先報道了一類離子結合型T6SS效應蛋白在離子轉運和細菌抗環境脅迫及宿主營養免疫中發揮重要作用；2）以谷氨酸棒桿菌為模型系統揭示了分枝硫醇在細菌抗多重環境脅迫中的多樣化作用機制；3）發現細菌鞭毛三型分泌系統伴侶蛋白FliS通過與FlgM相互作用而抑制其分泌，進而影響細菌鞭毛系統基因表達調控，從而揭示了鞭毛系統基因表達的關閉機制。　

承擔科研項目情況： 

1. 國家自然科學基金杰出青年基金“微生物環境適應機制(31725003)”，2018-2022，主持。

2. 國家重點研發計劃合成生物學專項“難降解有毒污染物智能生物降解體系”課題“難降解有毒污染物智能降解體系的設計與裝配” （SQ2018YFA090024-03），2019-2024，主持。 

3. 陜西省“高層次人才特殊支持計劃”科技創新領軍人才，2019-2024，主持。 

4. 國家自然科學基金面上項目“細菌VI型分泌系統轉運金屬離子的功能及機制研究 (31670053)”，2017-2020，主持。 

5. 國家自然科學基金面上項目“谷氨酸棒桿菌對木質纖維素糖化液中酚類抑制物質的耐受機理研究(31270078)”， 2013-2016，主持。 

6. 國家自然科學基金面上項目“假結核耶爾森氏菌VI型分泌系統的動力學分泌機制研究(31170121)” ，2012-2015 ，主持。

7. 科技部863“新型農業微生物肥效制劑的創制(2013AA102802)”子課題，2013-2017，主持。 

8. 陜西省農業攻關計劃“秸稈糖化液高效利用微生物細胞工廠的構建技術研究(2014K02-12-01)”， 2014-2016，主持。

發明公開：

[1]沈錫輝, 郭勝志, 王瑤, 賈思雨, 尹雁玲, 潘君風, 廖俊. 一種防治小麥莖基腐病的生防菌、生防菌劑及應用[P]. 陜西省: CN118406589A, 2024-07-30.

[2]沈錫輝, 郭勝志, 王瑤, 賈思雨, 尹雁玲, 張笑笑, 蔣欣燕, 李長富. 一種哈瓦斯假單胞菌、生防菌劑及應用[P]. 陜西省: CN118222449A, 2024-06-21.

[3]沈錫輝, 任兆銳, 何海洋, 朱玲芳, 李長富, 李書宇, 王瑤. 一種激活真菌沉默基因簇表達的方法[P]. 陜西省: CN118207236A, 2024-06-18.

[4]沈錫輝, 李長富, 朱玲芳, 魏志艷, 左煜昕, 王珂楠, 王瑤. 一種激活放線菌沉默次生代謝產物合成基因簇表達的方法[P]. 陜西省: CN117625430A, 2024-03-01.

[5]李丹萍, 劉永德, 劉海, 陳春磊, 張彥雄, 郝新偉, 沈錫輝, 毛婷婷. 一種解磷菌及其在鹽堿地的應用[P]. 浙江省: CN115322923A, 2022-11-11.

[6]沈錫輝, 石振堃, 宋莉, 瞿熠晨, 解瑩春, 寇春華, 徐磊, 王瑤. 假結核耶爾森氏菌效應蛋白及其應用[P]. 陜西省: CN114921438A, 2022-08-19.

[7]沈錫輝, 左煜昕, 朱玲芳, 劉雨琦, 余丹洋, 王柯楠. 一種假結核耶爾森氏菌抗真菌蛋白、應用及分離純化方法[P]. 陜西省: CN114703166A, 2022-07-05.

[8]翁為民, 劉永德, 陳春磊, 劉海, 張彥雄, 郝新偉, 沈錫輝, 毛婷婷. 一株耐低溫耐鹽堿解磷菌及培養方法及其應用[P]. 浙江省: CN114634887A, 2022-06-17.

[9]沈錫輝, 楊亞東, 王瑤, 孫宇, 唐亞楠, 肖志博. 一種大腸桿菌突變體的構建方法及外膜囊泡的制備方法[P]. 陜西省: CN113755514A, 2021-12-07.

[10]沈錫輝, 李夢園, 朱玲芳, 徐磊, 李長富, 王瀟, 劉欽萌, 楊亞東, 王瑤. 一種蛋白型錳離子螯合劑、免疫抑制劑及應用[P]. 陜西省: CN111569047A, 2020-08-25.

[11]沈錫輝, 潘君風, 宋莉, 徐磊, 張磊, 王瑤. 一種假結核耶爾森氏菌殺蟲蛋白及其編碼基因和應用[P]. 陜西: CN108586587A, 2018-09-28.

[12]沈錫輝, 李書宇, 張磊, 王瑤. 一株駱駝刺泛菌突變株PA11ZM1的篩選方法及其應用[P]. 陜西: CN108546652A, 2018-09-18.

[13]沈錫輝, 潘君風, 宋莉, 楊昶杏, 徐磊, 張磊, 王瑤. 一種假結核耶爾森氏菌抗真菌蛋白及其編碼基因和應用[P]. 陜西: CN108486085A, 2018-09-04.

[14]張磊, 陳超瓊, 辛凱蕓, 沈錫輝. 一株促作物抗干旱的歐文氏菌新種及其應用[P]. 陜西: CN105754900A, 2016-07-13.

[15]張磊, 辛凱蕓, 沈錫輝. 一株具有促植物抗干旱作用的克雷伯氏菌及其應用[P]. 陜西: CN105754901A, 2016-07-13.

[16]沈錫輝, 司美茹, 封嚴嚴, 王鐵濤, 陳燦, 潘君風, 張磊, 王瑤. 一個新型細菌抗逆功能基因及其表達產物與應用[P]. 陜西: CN104878023A, 2015-09-02.

[17]沈錫輝, 崔博宇, 宋云洪, 司美茹, 王瑤. 一種制備增強型單體細菌熒光素酶luxAB的方法[P]. 陜西: CN104178463A, 2014-12-03.

[18]沈錫輝, 葛云輝, 劉應保, 司美茹, 劉翔, 韋林芳, 李夢琪, 李玉菲, 崔博宇, 王瑤. 一株可高效降解木質素的乙酸鈣不動桿菌[P]. 陜西: CN104017753A, 2014-09-03.

[19]沈錫輝, 王瑤, 崔博宇, 宋云洪, 王鐵濤, 劉應保, 司美茹. 基于細菌熒光素酶BRET技術檢測蛋白質相互作用的方法[P]. 陜西: CN103616502A, 2014-03-05.

[20]王瑤, 崔博宇, 沈錫輝, 宋云洪, 劉應保. 增強型單體細菌熒光素酶基因luxAB及其應用[P]. 陜西: CN103160528A, 2013-06-19.

[21]劉雙江, 吳建峰, 劉志培, 王保軍, 姜成英, 沈錫輝. 一種降解對氯代硝基苯的睪丸酮叢毛單胞菌及其用途[P]. 北京: CN1616650, 2005-05-18.

[22]劉志培, 李習武, 劉雙江, 楊惠芳, 賈省芬, 沈錫輝, 吳建峰. 一種產生生物乳化劑和降解多環芳烴的赤紅球菌Em及用途[P]. 北京: CN1519312, 2004-08-11.

發明授權： 

[1]沈錫輝, 左煜昕, 朱玲芳, 劉雨琦, 余丹洋, 王柯楠. 一種假結核耶爾森氏菌抗真菌蛋白、應用及分離純化方法[P]. 陜西省: CN114703166B, 2023-07-28.

[2]翁為民, 劉永德, 陳春磊, 劉海, 張彥雄, 郝新偉, 沈錫輝, 毛婷婷. 一株耐低溫耐鹽堿解磷菌及培養方法及其應用[P]. 浙江省: CN114634887B, 2023-07-04.

[3]沈錫輝, 楊亞東, 王瑤, 孫宇, 唐亞楠, 肖志博. 一種大腸桿菌突變體的構建方法及外膜囊泡的制備方法[P]. 陜西省: CN113755514B, 2023-06-16.

[4]李丹萍, 劉永德, 劉海, 陳春磊, 張彥雄, 郝新偉, 沈錫輝, 毛婷婷. 一種解磷菌及其在鹽堿地的應用[P]. 浙江省: CN115322923B, 2023-06-13.

[5]沈錫輝, 李夢園, 朱玲芳, 徐磊, 李長富, 王瀟, 劉欽萌, 楊亞東, 王瑤. 一種蛋白型錳離子螯合劑、免疫抑制劑及應用[P]. 陜西省: CN111569047B, 2023-02-10.

[6]張磊, 辛凱蕓, 沈錫輝. 一株具有促植物抗干旱作用的克雷伯氏菌及其應用[P]. 陜西省: CN105754901B, 2020-07-07.

[7]沈錫輝, 潘君風, 宋莉, 楊昶杏, 徐磊, 張磊, 王瑤. 一種假結核耶爾森氏菌抗真菌蛋白及其編碼基因和應用[P]. 陜西省: CN108486085B, 2020-05-05.

[8]沈錫輝, 潘君風, 宋莉, 徐磊, 張磊, 王瑤. 一種假結核耶爾森氏菌殺蟲蛋白及其編碼基因和應用[P]. 陜西省: CN108586587B, 2020-05-05.

[9]張磊, 陳超瓊, 辛凱蕓, 沈錫輝. 一株促作物抗干旱的歐文氏菌新種及其應用[P]. 陜西省: CN105754900B, 2020-04-17.

[10]沈錫輝, 崔博宇, 宋云洪, 司美茹, 王瑤. 一種制備增強型單體細菌熒光素酶luxAB的方法[P]. 陜西省: CN104178463B, 2017-06-20.

[11]沈錫輝, 葛云輝, 劉應保, 司美茹, 劉翔, 韋林芳, 李夢琪, 李玉菲, 崔博宇, 王瑤. 一株可降解木質素的乙酸鈣不動桿菌[P]. 陜西省: CN104017753B, 2017-01-11.

[12]沈錫輝, 王瑤, 崔博宇, 宋云洪, 王鐵濤, 劉應保, 司美茹. 基于細菌熒光素酶BRET技術檢測蛋白質相互作用的方法[P]. 陜西省: CN103616502B, 2016-05-25.

[13]王瑤, 崔博宇, 沈錫輝, 宋云洪, 劉應保. 增強型單體細菌熒光素酶基因luxAB及其應用[P]. 陜西省: CN103160528B, 2014-06-11.

[14]劉雙江, 吳建峰, 劉志培, 王保軍, 姜成英, 沈錫輝. 一種降解對氯代硝基苯的睪丸酮叢毛單胞菌及其用途[P]. 北京市: CN1313598C, 2007-05-02.

[15]劉志培, 李習武, 劉雙江, 楊惠芳, 賈省芬, 沈錫輝, 吳建峰. 一種產生生物乳化劑和降解多環芳烴的赤紅球菌Em及用途[P]. 北京市: CN1223673C, 2005-10-19.

發表英文文章 (*為通訊作者)：  

[1]Li, Shuyu; Liu, Qinmeng; Duan, Chongyi; Li, Jialin; Sun, Hengxi; Xu, Lei; Yang, Qiao; Wang, Yao; Shen, Xihui*; Zhang, Lei*. c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella.Nature Communications, 2023, 14(1): 7502.

[2]Wu, Tong; Guo, Sheng-Zhi; Zhu, Hai-Zhen; Yan, Lei; Liu, Zhi-Pei; Li, De-Feng; Jiang, Cheng-Ying; Corvini, Philippe Francois-Xavier; Shen, Xi-Hui*; Liu, Shuang-Jiang*.The sulfonamide-resistance dihydropteroate synthase gene is crucial for efficient biodegradation of sulfamethoxazole by Paenarthrobacter species.Applied Microbiology and Biotechnology, 2023, 107(18): 5813-5827.

[3]Hao, Xinwei; Wang, Xiao; Chen, Chunlei; Liu, Ruirui; Yin, Yanling; Yao, Jun; Xiao, Zhibo; Liu, Xiaozhen; Shen, Xihui*; Liu, Xingyu*.Synthetic bacterial communities reshape microbial communities and enhance nutrient supply in desertified land of Northwest China.Applied Soil Ecology, 2023, 189: 104972.

[4]Liu, Hai; Wei, Zhiyan; Li, Jiali; Liu, Xingyu; Zhu, Lingfang; Wang, Yao; Wang, Tietao*; Li, Changfu*; Shen, Xihui.A Yersinia T6SS Effector YezP Engages the Hemin Uptake Receptor HmuR and ZnuABC for Zn2+ Acquisition.Applied and Environmental Microbiology, 2023, 89(7).

[5]Wang, Xiao; Tang, Jingjing; Dang, Wen; Xie, Zhen; Zhang, Fuhua; Hao, Xinwei; Sun, Sihuai; Liu, Xuan; Luo, Yi; Li, Mengyuan; Gu, Yanchao; Wang, Yao; Chen, Qiwei*; Shen, Xihui*; Xu, Lei*.Isolation and Characterization of Three Pseudomonas aeruginosa Viruses with Therapeutic Potential.Microbiology Spectrum, 2023, 11(3): e04636-22.

[6]Liu, Yang; Wang, Hao; Qian, Xun; Gu, Jie; Chen, Weimin; Shen, Xihui; Tao, Shiheng; Jiao, Shuo*; Wei, Gehong*.Metagenomics insights into responses of rhizobacteria and their alleviation role in licorice allelopathy.Microbiome, 2023, 11(1): 109.

[7]Kong, Jia; Hu, Jinyao; Li, Jia; Zhang, Jiaxing; Shen, Yuhe; Yue, Tianli; Shen, Xihui; Wang, Yuefei*; Li, Zhonghong*; Xia, Yinqiang*.Rethreading Design of Ratiometric roGFP2 Mimetic Peptide for Hydrogen Peroxide Sensing.Analytical Chemistry, 2023, 95(21): 8284-8290.

[8]Kong, Jia*; Zhao, Shixuan; Han, Xue; Li, Wenxin; Zhang, Jiaxing; Wang, Yuefei; Shen, Xihui; Xia, Yinqiang*; Li, Zhonghong*.Quantitative Ratiometric Biosensors Based on Fluorescent Ferrocene-Modified Histidine Dipeptide Nanoassemblies.Analytical Chemistry, 2023, 95(11): 5053-5060.

[9]Gu, Yanchao; Tang, Jingjing; Zhang, Fuhua; Qu, Yichen; Zhao, Min; Li, Mengyuan; Xie, Zhen; Wang, Xiao; Song, Li; Jiang, Zhengfan; Wang, Yao*; Shen, Xihui*; Xu, Lei*.Manganese potentiates lipopolysaccharide-induced innate immune responses and septic shock.International Journal of Biological Macromolecules, 2023, 230: 123202.

[10]Wang, Zhuo; Song, Li; Liu, Xiaozhen; Shen, Xihui; Li, Xin*.Bacterial second messenger c-di-GMP: Emerging functions in stress resistance.Microbiological Research, 2023, 268: 127302.

[11]Lin, Jinshui; Yang, Jianshe; Cheng, Juanli; Zhang, Weipeng; Yang, Xu; Ding, Wei; Zhang, Heng; Wang, Yao; Shen, Xihui*.Pseudomonas aeruginosa H3-T6SS Combats H2O2 Stress by Diminishing the Amount of Intracellular Unincorporated Iron in a Dps-Dependent Manner and Inhibiting the Synthesis of PQS.International Journal of Molecular Sciences, 2023, 24(2): 1614.

[12]Wang, Dandan; Zhu, Lingfang; Zhen, Xiangkai; Yang, Daoyan; Li, Changfu; Chen, Yating; Wang, Huannan; Qu, Yichen; Liu, Xiaozhen; Yin, Yanling; Gu, Huawei; Xu, Lei; Wan, Chuanxing; Wang, Yao; Ouyang, Songying*; Shen, Xihui*.A secreted effector with a dual role as a toxin and as a transcriptional factor.Nature Communications, 2022, 13(1): 7779.

[13]Li, Shuyu; Sun, Hengxi; Li, Jianghan; Zhao, Yujiao; Wang, Ruiying; Xu, Lei; Duan, Chongyi; Li, Jialin; Wang, Zhuo; Liu, Qinmeng; Wang, Yao; Ouyang, Songying*; Shen, Xihui*; Zhang, Lei*.Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone.Nature Communications, 2022, 13(1): 6684.

[14]Liu, Xiaozhen; Liu, Qinmeng; Sun, Sihuai; Sun, Hengxi; Wang, Yao; Shen, Xihui*; Zhang, Lei*.Exploring AI-2-mediated interspecies communications within rumen microbial communities.Microbiome, 2022, 10(1): 167.

[15]Xu, Lei; Li, Mengyuan; Yang, Yadong; Zhang, Chen; Xie, Zhen; Tang, Jingjing; Shi, Zhenkun; Chen, Shukun; Li, Guangzhe; Gu, Yanchao; Wang, Xiao; Zhang, Fuhua; Wang, Yao; Shen, Xihui*.Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release.mBio, 2022, 13(3). 

[16]Wang, Zhuo; Xie, Xiaorong; Shang, Daohan; Xie, Laigong; Hua, Yueyue; Song, Li; Yang, Yantao; Wang, Yao; Shen, Xihui*; Zhang, Lei*.A c-di-GMP Signaling Cascade Controls Motility, Biofilm Formation, and Virulence in Burkholderia thailandensis.Applied and Environmental Microbiology, 2022, 88(7): e02529-21.

[17]Guo, Sheng-Zhi; Wu, Tong; Zhu, Hai-Zhen; Yan, Lei; Liu, Zhi-Pei; Li, De-Feng; Jiang, Cheng-Ying; Liu, Shuang-Jiang*; Shen, Xi-Hui*.Niabella beijingensis sp. nov. and Thermomonas beijingensis sp. nov., two bacteria from constructed wetland.International Journal of Systematic and Evolutionary Microbiology, 2022, 72(3): 005280.

[18]Wang Chenguang#; Xu Lei#; Zhu Lingfang#; Li Changfu; Li Mengyuan; Liu Qinmeng; Yang Wenhui; Pan Damin; Hu Lingfei; Yang Yadong; Lu Zhiqiang; Wang Yao; Zhou Dongsheng*; Jiang Zhengfan*; Shen Xihui*.T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese.Proc Natl Acad Sci U S A., 2021, 118(42): e2103526118.

[19]Lei Xu#; Jinshui lin#; Jianshe Yang; Zhuo Wang; Xihui Shen*.Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance.Stress Biology, 2021, 1(1): 11.

[20]Li Changfu#; Zhu Lingfang#; Wang dandan#; Wei Zhiyan; Hao Xinwei; Wang Zhuo; Li Tengfei; Zhang Lei; Lu Zhiqiang; Long Mingxiu; Wang Yao*; Wei Gehong*; Shen Xihui*.T6SS secretes an LPS-binding effector to recruit OMVs for exploitative competition and horizontal gene transfer.ISME J, 2021, Online ahead of prin(.): ..

[21]Cai, Ran; Gao, Fen; Pan, Junfeng; Hao, Xinwei; Yu, Zonglan; Qu, Yichen; Li, Jialin; Wang, Dandan; Wang, Yao; Shen, Xihui; Liu, Xingyu*; Yang, Yantao*.The transcriptional regulator Zur regulates the expression of ZnuABC and T6SS4 in response to stresses in Yersinia pseudotuberculosis.Microbiological Research, 2021, 249: 126787.

[22]Li, Changfu; Pan, Damin; Li, Mengyuan; Wang, Yao; Song, Luting; Yu, Danyang; Zuo, Yuxin; Wang, Kenan; Liu, Yuqi; Wei, Zhiyan; Lu, Zhiqiang; Zhu, Lingfang*; Shen, Xihui*.Aerobactin-Mediated Iron Acquisition Enhances Biofilm Formation, Oxidative Stress Resistance, and Virulence of Yersinia pseudotuberculosis.Frontiers in Microbiology, 2021, 12: 699913.

[23]Song, Li; Pan, Junfeng; Yang, Yantao; Zhang, Zhenxing; Cui, Rui; Jia, Shuangkai; Wang, Zhuo; Yang, Changxing; Xu, Lei; Dong, Tao G.; Wang, Yao*; Shen, Xihui*.Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties.Nature Communications, 2021, 12(1): 423.

[24]Luo, Yantao; Liu, Dongying; Jiao, Shuo; Liu, Shuang; Wang, Xinye; Shen, Xihui; Wei, Gehong*.Identification of Robinia pseudoacacia target proteins responsive to Mesorhizobium amphore CCNWGS0123 effector protein NopT.Journal of Experimental Botany, 2020, 71(22): 7347-7363.

[25]Zhang, Lei*; Li, Shuyu; Liu, Xiaozhen; Wang, Zhuo; Jiang, Mei; Wang, Ruiying; Xie, Laigong; Liu, Qinmeng; Xie, Xiaorong; Shang, Daohan; Li, Mengyun; Wei, Zhiyan; Wang, Yao; Fan, Chengpeng; Luo, Zhao-Qing*; Shen, Xihui*.Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes.Nature Communications, 2020, 11(1): 5371.

[26]Zhang, Lei; Zhang, Weipeng; Li, Qiqi; Cui, Rui; Wang, Zhuo; Wang, Yao; Zhang, Yu-Zhong; Ding, Wei*; Shen, Xihui*.Deciphering the Root Endosphere Microbiome of the Desert Plant Alhagi sparsifolia for Drought Resistance-Promoting Bacteria.Applied and Environmental Microbiology, 2020, 86(11): e02863-19.

[27]Wang, Zhuo; Wang, Tietao; Cui, Rui; Zhang, Zhenxing; Chen, Keqi; Li, Mengyun; Hua, Yueyue; Gu, Huawei; Xu, Lei; Wang, Yao; Yang, Yantao*; Shen, Xihui*.HpaR, the Repressor of Aromatic Compound Metabolism, Positively Regulates the Expression of T6SS4 to Resist Oxidative Stress in Yersinia pseudotuberculosis.Frontiers in Microbiology, 2020, 11: 705. 

[28]Zhang, Bing; Gu, Huawei; Yang, Yantao; Bai, Haonan; Zhao, Chao; Si, Meiru; Su, Tao*; Shen, Xihui*.Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis.Frontiers in Microbiology, 2019, 10: 1483.

[29]Chen, Can; Yang, Xiaobing; Shen, Xihui*.Confirmed and Potential Roles of Bacterial T6SSs in the Intestinal Ecosystem.Frontiers in Microbiology, 2019, 10: 1484.

[30]Li, Shuyu; Liang, Hong; Wei, Zhiyan; Bai, Haonan; Li, Mengyun; Li, Qiqi; Qu, Meng; Shen, Xihui; Wang, Yao*; Zhang, Lei*.An Osmoregulatory Mechanism Operating through OmpR and LrhA Controls the Motile-Sessile Switch in the Plant GrowthPromoting Bacterium Pantoea alhagi.Applied and Environmental Microbiology, 2019, 85(10): UNSP e00077-19.

[31]Ma, Li; Zhou, Lizhen; Lin, Jinshui; Ji, Jiuyuan; Wang, Yang; Jiang, Haobo; Shen, Xihui; Lu, Zhiqiang*.Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa.Developmental and Comparative Immunology, 2019, 90: 176-185. 

[32]Li, Changfu; Zhu, Lingfang; Pan, Damin; Li, Shuyu; Xiao, He; Zhang, Zhenxing; Shen, Xihui; Wang, Yao*; Long, Mingxiu*.Siderophore-Mediated Iron Acquisition Enhances Resistance to Oxidative and Aromatic Compound Stress in Cupriavidus necator JMP134.Applied and Environmental Microbiology, 2019, 85(1): UNSP e01938-18.

[33]Yang, Xiaobing; Pan, Junfeng; Wang, Yao; Shen, Xihui*.Type VI Secretion Systems Present New Insights on Pathogenic Yersinia.Frontiers in Cellular and Infection Microbiology, 2018, 8: 260. 

[34]Lin Jinshui*; Cheng Juanli; Wang Yao; Shen Xihui*.The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore.Frontiers in Cellular and Infection Microbiology, 2018, 8: 230.

[35]Zhang Lei*; Li Muhang; Li Qiqi; Chen Chaoqiong; Qu Meng; Li Mengyun; Wang Yao; Shen Xihui*.The Catabolite Repressor/Activator Cra Is a Bridge Connecting Carbon Metabolism and Host Colonization in the Plant Drought Resistance-Promoting Bacterium Pantoea alhagi LTYR-11Z.Applied and Environmental Microbiology, 2018, 84(13): UNSP e00054-18.

[36]Yang Xiaobing; Long Mingxiu; Shen Xihui*.Effector-Immunity Pairs Provide the T6SS Nanomachine its Offensive and Defensive Capabilities.Molecules, 2018, 23(5): 1009. 

[37]Dai, Qingyun; Xu, Lei; Xiao, Lu; Zhu, Kaixiang; Song, Yunhong; Li, Changfu; Zhu, Lingfang; Shen, Xihui*; Wang, Yao*.RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis.Frontiers in Microbiology, 2018, 9: 348.

[38]Zhang, Lei*; Li, Qiqi; Chen, Chaoqiong; Li, Xin; Li, Muhang; Hu, Jingjiang; Shen, Xihui*.Propioniciclava sinopodophylli sp nov., isolated from leaves of Sinopodophyllum hexandrum (Royle) Ying.INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2017, 67(10): 4111-4115.

[39]Xu, Yixiang; Wang, Chao; Zhang, Gang; Tian, Jingjing; Liu, Ying; Shen, Xihui*; Feng, Jie*.ISCR2 is associated with the dissemination of multiple resistance genes among Vibrio spp. and Pseudoalteromonas spp. isolated from farmed fish.ARCHIVES OF MICROBIOLOGY, 2017, 199(6): 891-896.

[40]Si, Meiru; Wang, Yao; Zhang, Bing; Zhao, Chao; Kang, Yiwen; Bai, Haonan; Wei, Dawei; Zhu, Lingfang; Zhang, Lei; Dong, Tao G.; Shen, Xihui*.The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition.CELL REPORTS, 2017, 20(4): 949-959.

[41]Wang, Tietao; Chen, Keqi; Gao, Fen; Kang, Yiwen; Chaudhry, Muhammad Tausif; Wang, Zhuo; Wang, Yao*; Shen, Xihui*.ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis.Journal of Microbiology, 2017, 55(6): 448-456. 

[42]Zhao Ruoxi; Song Yunhong; Dai Qingyun; Kang Yiwen; Pan Junfeng; Zhu Lingfang; Zhang Lei; Wang Yao; Shen Xihui.A starvation-induced regulator, RovM, acts as a switch for planktonic/biofilm state transition in Yersinia pseudotuberculosis.Scientific Reports, 2017, 7(1): 639.

[43]Lin, Jinshui; Zhang, Weipeng; Cheng, Juanli; Yang, Xu; Zhu, Kaixiang; Wang, Yao; Wei, Gehong; Qian, Pei-Yuan; Luo, Zhao-Qing; Shen, Xihui*.A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition.Nature Communications, 2017, 8: 14888.

[44]Zhang, Lei; Zhong, Jun; Liu, Hao; Xin, Kaiyun; Chen, Chaoqiong; Li, Qiqi; Wei, Yahong; Wang, Yao; Chen, Fei*; Shen, Xihui*.Complete genome sequence of the drought resistance-promoting endophyte Klebsiella sp LTGPAF-6F.Journal of Biotechnology, 2017, 246: 36-39. 

[45]Si, Meiru; Zhao, Chao; Burkinshaw, Brianne; Zhang, Bing; Wei, Dawei; Wang, Yao; Dong, Tao G.*; Shen, Xihui*.Manganese scavenging and oxidative stress response mediated by type VI secretion system in Burkholderia thailandensis.Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(11):E2233-E2242. (cited by Faculty of 1000 Prime) 

[46]Xin, Kaiyun; Li, Muhang; Chen, Chaoqiong; Yang, Xu; Li, Qiqi; Cheng, Juanli; Zhang, Lei*; Shen, Xihui*.Paenibacillus qinlingensis sp nov., an indole-3-acetic acid-producing bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying.International Journal of Systematic and Evolutionary Microbiology, 2017, 67(3): 589-595. 

[47]Chen, Can; Pan, Junfeng; Yang, Xiaobing; Xiao, He; Zhang, Yaoling; Si, Meiru; Shen, Xihui*; Wang, Yao*.Global transcriptomic analysis of the response of Corynebacterium glutamicum to ferulic acid.Archives of Microbiology, 2017, 199(2): 325-334.

[48]Chaoqiong; Kaiyun Xin; Hao Liu; Juanli Cheng; Xihui Shen; Yao Wang; Lei Zhang*.Pantoea alhagi, a novel endophytic bacterium with ability to improve growth and drought tolerance in wheat.Scientific Reports, 2017, 7: 41564.

[49]Meiru Si; Tietao Wang; Junfeng Pan; Jinshui Lin; Can Chen; Yahong Wei; Zhiqiang Lu; Gehong Wei; Xihui Shen*.Graded Response of the Multifunctional 2-Cysteine Peroxiredoxin, CgPrx, to Increasing Levels of Hydrogen Peroxide in Corynebacterium glutamicum.Antioxidants & Redox Signaling, 2017, 26(1): 1-14.

[50]Si, Meiru; Feng, Yanyan; Chen, Keqi; Kang, Yiwen; Chen, Can; Wang, Yao*; Shen, Xihui*.Functional comparison of methionine sulphoxide reductase A and B in Corynebacterium glutamicum.JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2017, 63(5): 280-286.

[51]Chen, Chaoqiong; Xin, Kaiyun; Li, Muhang; Li, Xin; Cheng, Juanli; Zhang, Lei*; Shen, Xihui*.Paenibacillus sinopodophylli sp nov., a siderophore-producing endophytic bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying.International Journal of Systematic and Evolutionary Microbiology, 2016, 66(12): 4993-4999.

[52]Chen, Can; Pan, Junfeng; Yang, Xiaobing; Guo, Chenghao; Ding, Wei; Si, Meiru; Zhang, Yi; Shen, Xihui*; Wang, Yao*.Global Transcriptomic Analysis of the Response of Corynebacterium glutamicum to Vanillin.PLos One, 2016, 11(10): e0164955.

[53]Sihuai Sun#; Xiaobing Yang#; Yao Wang; Xihui Shen*.In Vivo Analysis of Protein-Protein Interactions with Bioluminescence Resonance Energy Transfer (BRET): Progress and Prospects.Int J Mol Sci., 2016, 17(10): pii: E1704.

[54]Liang, Jianqiang; Zhang, Mingzhe; Lu, Mingmei; Li, Zhefei; Shen, Xihui; Chou, Minxia*; Wei, Gehong*。Functional characterization of a csoR-cueA divergon in Bradyrhizobium liaoningense CCNWSX0360, involved in copper, zinc and cadmium cotolerance.Scientific Reports, 2016, 6: 35155.

[55]Shi, Xu; Li, Changfu; Zhao, Liang; Si, Meiru; Zhu, Lingfang; Xin, Kaiyun; Chen, Chaoqiong; Wang, Yao; Shen, Xihui; Zhang, Lei*.Rhizobium gei sp nov., a bacterial endophyte of Geum aleppicum.International Journal of Systematic and Evolutionary Microbiology, 2016, 66: 4282-4288.

[56]Wang, Tietao; Yang, Xiaobing; Gao, Fen; Zhao, Chao; Kang, Yiwen; Wang, Yao; Shen, Xihui*.Zinc acquisition via ZnuABC in Yersinia pseudotuberculosis facilitates resistance to oxidative stress.Annals of Microbiology, 2016, 66(3): 1189-1197.

[57]Si, Meiru; Zhao, Chao; Zhang, Bing; Wei, Dawei; Chen, Keqi; Yang, Xu; Xiao, He; Shen, Xihui*.Overexpression of Mycothiol Disulfide Reductase Enhances Corynebacterium glutamicum Robustness by Modulating Cellular Redox Homeostasis and Antioxidant Proteins under Oxidative Stress.Scientific Reports, 2016, 6: 29491.

[58]Wang, Tietao; Gao, Fen; Kang, Yiwen; Zhao, Chao; Su, Tao; Li, Muhang; Si, Meiru; Shen, Xihui*.Mycothiol peroxidase MPx protects Corynebacterium glutamicum against acid stress by scavenging ROS.Biotechnology Letters, 2016, 38(7): 1221-1228.

[59]Liu, Yingbao; Yang, Xiaobing; Yin, Yajie; Lin, Jinshui; Chen, Can; Pan, Junfeng; Si, Meiru*; Shen, Xihui*.Mycothiol protects Corynebacterium glutamicum against acid stress via maintaining intracellular pH homeostasis, scavenging ROS, and S-mycothiolating MetE.Journal of General and Applied Microbiology, 2016, 62(3): 144-153. 

[60]Akbar, Ali; Chen, Chaoqiong; Zhu, Lingfang; Xin, Kaiyun; Cheng, Juanli; Yang, Qiao; Zhao, Liang; Zhang, Lei*; Shen, Xihui.Sphingomonas hylomeconis sp nov., isolated from the stem of Hylomecon japonica.International Journal of Systematic and Evolutionary Microbiology, 2015, 65: 4025-4031.

[61]Song, Yunhong; Xiao, Xiao; Li, Changfu; Wang, Tietao; Zhao, Ruoxi; Zhang, Weipeng; Zhang, Lei; Wang, Yao; Shen, Xihui*.The dual transcriptional regulator RovM regulates the expression of AR3- and T6SS4-dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis.Environmental Microbiology, 2015, 17(11): 4631-4645.

[62]Guan, Jingyuan; Xiao, Xiao; Xu, Shengjuan; Gao, Fen; Wang, Jianbo; Wang, Tietao; Song, Yunhong; Pan, Junfeng; Shen, Xihui*; Wang, Yao*.Roles of RpoS in Yersinia pseudotuberculosis stress survival, motility, biofilm formation and type VI secretion system expression.Journal of Microbiology, 2015, 53(9): 633-642.

[63]Xiao, Xiao#; Si, Meiru#; Yang, Zhifang; Zhang, Yaoling; Guan, Jingyuan; Chaudhry, Muhammad Tausif; Wang, Yao; Shen, Xihui*.Molecular characterization of a eukaryotic-like phenol hydroxylase from Corynebacterium glutamicum.Journal of General and Applied Microbiology, 2015, 61(4): 99-107.

[64]Si, Meiru; Xu, Yixiang; Wang, Tietao; Long, Mingxiu; Ding, Wei; Chen, Can; Guan, Xinmeng; Liu, Yingbao; Wang, Yao; Shen, Xihui*; Liu, Shuang-Jiang.Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems in the response to oxidative stress.Biochemical Journal. 2015, 469(1):45-57. 

[65]Wang, Tietao#; Si, Meiru#; Song, Yunhong#; Zhu, Wenhan; Gao, Fen; Wang, Yao; Zhang, Lei; Zhang, Weipeng; Wei, Gehong; Luo, Zhao-Qing; Shen, Xihui*.Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity.PLoS Pathogens, 2015, 11(7): e1005020.

[66]Si, Meiru#; Wang, Jianbo#; Xiao, Xiao; Guan, Jingyuan; Zhang, Yaoling; Ding, Wei; Chaudhry, Muhammad Tausif; Wang, Yao*; Shen, Xihui*.Ohr Protects Corynebacterium glutamicum against Organic Hydroperoxide Induced Oxidative Stress.PLos One, 2015, 10(6): e0131634.

[67]Zhang, Weipeng; Sun, Jin; Ding, Wei; Lin, Jinshui; Tan, Renmao; Lu, Liang; Liu, Xiaofen; Shen, Xihui; Qian, Pei-Yuan*.Extracellular matrix-associated proteins form an integral and dynamic system during Pseudomonas aeruginosa biofilm development.Frontiers in Cellular and Infection Microbiology, 2015, 5: 40.

[68]Zhu, Lingfang#; Xin, Kaiyun#; Chen, Chaoqiong; Li, Changfu; Si, Meiru; Zhao, Liang; Shi, Xu; Zhang, Lei*; Shen, Xihui*.Sphingobium endophyticus sp nov., isolated from the root of Hylomecon japonica.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2015, 107(4): 1001-1008.

[69]Si, Meiru#; Zhang, Lei#; Chaudhry, Muhammad Tausif#; Ding, Wei; Xu, Yixiang; Chen, Can; Akbar, Ali; Shen, Xihui*; Liu, Shuang-Jiang.Corynebacterium glutamicum Methionine Sulfoxide Reductase A Uses both Mycoredoxin and Thioredoxin for Regeneration and Oxidative Stress Resistance.Applied and Environmental Microbiology, 2015, 81(8): 2781-2796.

[70]Zhu, Lingfang; Si, Meiru; Li, Changfu; Xin, Kaiyun; Chen, Chaoqiong; Shi, Xu; Huang, Ruijun; Zhao, Liang; Shen, Xihui; Zhang, Lei*。Sphingomonas gel sp nov., isolated from roots of Geum aleppicum.International Journal of Systematic and Evolutionary Microbiology, 2015, 65: 1160-1166.

[71]Wei, Linfang; Si, Meiru; Long, Mingxiu; Zhu, Lingfang; Li, Changfu; Shen, Xihui; Wang, Yao; Zhao, Liang; Zhang, Lei*.Rhizobacter bergeniae sp nov., isolated from the root of Bergenia scopulosa.International Journal of Systematic and Evolutionary Microbiology, 2015, 65: 479-484.

[72]Ding Wei#; Meiru Si#; Weipeng Zhang; Yaoling Zhang; Can Chen; Lei Zhang; Zhiqiang Lu; Shaolin Chen; Xihui Shen*.Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum.Scientific Reports, 2015, 5(1): 8044.

[73]Lin, Jinshui#; Cheng, Juanli#; Chen, Keqi; Guo, Chenghao; Zhang, Weipeng; Yang, Xu; Ding, Wei; Ma, Li; Wang, Yao; Shen, Xihui*.The icmF3 locus is involved in multiple adaptation- and virulence-related characteristics in Pseudomonas aeruginosa PAO1.Front Cell Infect Microbiol, 2015, 5: 70.

[74]Si, Meiru; Long, Mingxiu; Chaudhry, Muhammad Tausif; Xu, Yixiang; Zhang, Pan; Zhang, Lei; Shen, Xihui*.Functional Characterization of Corynebacterium glutamicum Mycothiol S-Conjugate Amidase.PLos One, 2014, 9(12): e115075. 

[75]Zhu, Lingfang; Long, Mingxiu; Si, Meiru; Wei, Linfang; Li, Changfu; Zhao, Liang; Shen, Xihui; Wang, Yao; Zhang, Lei*.Asticcacaulis endophyticus sp nov., a prosthecate bacterium isolated from the root of Geum aleppicum.International Journal of Systematic and Evolutionary Microbiology, 2014, 64: 3964-3969.

[76]Cui, Boyu#; Zhang, Lifeng#; Song, Yunhong; Wei, Jinsong; Li, Changfu; Wang, Tietao; Wang, Yao; Zhao, Tianyong*; Shen, Xihui*.Engineering an Enhanced, Thermostable, Monomeric Bacterial Luciferase Gene As a Reporter in Plant Protoplasts.PLos One, 2014, 9(10): e107885.

[77]Zhang, Lei; Shi, Xu; Si, Meiru; Li, Changfu; Zhu, Lingfang; Zhao, Liang; Shen, Xihui; Wang, Yao*.Rhizobium smilacinae sp nov., an endophytic bacterium isolated from the leaf of Smilacina japonica.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 106(4): 715-723.

[78]Zhang, Lei#; Zhu, Lingfang#; Si, Meiru; Li, Changfu; Zhao, Liang; Wei, Yahong; Shen, Xihui*.Solirubrobacter taibaiensis sp nov., isolated from a stem of Phytolacca acinosa Roxb.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 106(2): 279-285. 

[79]Liu, Ying-Bao; Chen, Can; Chaudhry, Muhammad Tausif; Si, Mei-Ru; Zhang, Lei; Wang, Yao; Shen, Xi-Hui*.Enhancing Corynebacterium glutamicum robustness by over-expressing a gene, mshA, for mycothiol glycosyltransferase.Biotechnology Letters, 2014, 36(7): 1453-1459. 

[80]Cui, Boyu#; Wang, Yao#; Song, Yunhong; Wang, Tietao; Li, Changfu; Wei, Yahong; Luo, Zhao-Qing*; Shen, Xihui*.Bioluminescence Resonance Energy Transfer System for Measuring Dynamic Protein-Protein Interactions in Bacteria.mBio, 2014, 5(3): e01050-14.

[81]Zhang, Lei; Wei, Linfang; Zhu, Lingfang; Li, Changfu; Wang, Yao; Shen, Xihui*.Pseudoxanthomonas gei sp nov., a novel endophytic bacterium isolated from the stem of Geum aleppicum.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 105(4): 653-661.

[82]Xu, Shengjuan#; Peng, Zhong#; Cui, Boyu; Wang, Tietao; Song, Yunhong; Zhang, Lei; Wei, Gehong; Wang, Yao*; Shen, Xihui*.FliS modulates FlgM activity by acting as a non-canonical chaperone to control late flagellar gene expression, motility and biofilm formation in Yersinia pseudotuberculosis.Environmental Microbiology, 2014, 16(4): 1090-1104. (cited by Faculty of 1000 Prime)  

[83]Si, Mei-Ru#; Zhang, Lei#; Yang, Zhi-Fang; Xu, Yi-Xiang; Liu, Ying-Bao; Jiang, Cheng-Ying; Wang, Yao; Shen, Xi-Hui*; Liu, Shuang-Jiang.NrdH Redoxin Enhances Resistance to Multiple Oxidative Stresses by Acting as a Peroxidase Cofactor in Corynebacterium glutamicum.Applied and Environmental Microbiology, 2014, 80(5): 1750-1762.

[84]Wei, Linfang; Ouyang, Shan; Wang, Yao; Shen, Xihui; Zhang, Lei*.Solirubrobacter phytolaccae sp nova., an endophytic bacterium isolated from roots of Phytolacca acinosa Roxb.International Journal of Systematic and Evolutionary Microbiology, 2014, 64: 858-862.

[85]Zhang L; Si M; Zhu L; Li C; Wei Y; Shen X*.Draft genome sequence of Nafulsella turpanensis ZLM-10T, a novel member of the family Flammeovirgaceae.Genome Announc, 2014, 2(2).

[86]Zhang, Lei#; Zhu, Lingfang#; Wei, Linfang; Li, Changfu; Wang, Yao; Shen, Xihui*.Pontibacter toksunensis sp nov., isolated from soil, and emended descriptions of Pontibacter roseus and Pontibacter akesuensis.International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 4462-4468.

[87]Zhang, Lei; Wang, Yang; Wei, Linfang; Wang, Yao; Shen, Xihui*; Li, Shiqing.Taibaiella smilacinae gen. nov., sp nov., an endophytic member of the family Chitinophagaceae isolated from the stem of Smilacina japonica, and emended description of Flavihumibacter petaseus.International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 3769-3776.

[88]Liu Ying Bao; Long Ming Xiu; Yin Ya Jie; Si Mei Ru; Zhang Lei; Lu Zhi Qiang; Wang Yao; Shen Xi Hui*.Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum.Archives of Microbiology, 2013, 195(6): 419-429.

[89]Zhang, Lei; Shen, Xihui; Liu, Yingbao; Li, Shiqing*.Nafulsella turpanensis gen. nov., sp nov., a member of the phylum Bacteroidetes isolated from soil.International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 1639-1645.

[90]Ying-Bao Liu#; Ming-Xiu Long#; Ya-Jie Yin; Mei-Ru Si; Lei Zhang; Zhi-Qiang Lu; Yao Wang; Xi-Hui Shen*.Physiological roles of mycothiol in detoxification and tolerance to multiple poisounous chemicals in Corynebacterium glutamicum.Archives of Microbiology, 2013, 195(6): 419-429.

[91]Zhang, Weipeng#; Wang, Yao#; Song, Yunhong; Wang, Tietao; Xu, Shengjuan; Peng, Zhong; Lin, Xiaoli; Zhang, Lei; Shen, Xihui*.A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis.Environmental Microbiology, 2013, 15(2): 557-569.

[92]Shen, Xi-Hui; Zhou, Ning-Yi; Liu, Shuang-Jiang*.Degradation and assimilation of aromatic compounds by Corynebacterium glutamicum: Another potential for applications for this bacterium?.Applied Microbiology and Biotechnology, 2012, 95(1): 77-89.

[93]Gong, Jian; Shen, Xi-Hui; Qiu, Hui; Chen, Chao; Yang, Rong-Ge*.Rhesus Monkey TRIM5 alpha Has Distinct HIV-1 Restriction Activity Among Different Mammalian Cell Lines.Current Microbiology, 2011, 63(6): 531-537. 

[94]Gong, Jian; Shen, Xi-Hui; Qiu, Hui; Chen, Chao; Yang, Rong-Ge*.Rhesus monkey TRIM5 alpha represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-kappa B activation.Archives of Virology, 2011, 156(11): 1997-2006.

[95]Gong J; Wang XQ; Tong X; Shen XH,; Yang RG*.Emerging trends of drug-resistant HIV-1 among drug-treated patients in former blood donors in Hubei, China: a three-year surveillance from 2004 to 2006.Virologica Sinica, 2011, 6(6): 386-392.

[96]Zhang, Weipeng; Xu, Shengjuan; Li, Jing; Shen, Xihui; Wang, Yao*; Yuan, Zhiming*.Modulation of a thermoregulated type VI secretion system by AHL-dependent Quorum Sensing in Yersinia pseudotuberculosis.Archives of Microbiology, 2011, 193(5): 351-363.

[97]Jian Gong; Xi-Hui Shen; Hui Qiu; Chao Chen; Rong-Ge Yang*.Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway.Virologica Sinica, 2011, 26(2): 114-122. 

[98]Fontana, Mary F.; Banga, Simran; Barry, Kevin C.; Shen, Xihui; Tan, Yunhao; Luo, Zhao-Qing; Vance, Russell E.Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila.PLoS Pathogens, 2011, 7(2): e1001289.

[99]Xu, Li*; Shen, Xihui*; Bryan, Andrew; Banga, Simran; Swanson, Michele S.; Luo, Zhao-Qing*.Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector.PLoS Pathogens, 2010, 6(3): e1000822.

[100]Xihui Shen#, Simran Banga#, Yancheng Liu, Li Xu, Ping Gao, Ilya Shamovsky, Evgeny Nudler, Zhao-Qing Luo. Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cellular Microbiology. 2009, 11(6):911-926. 

[101]Huang, Yan; Zhao, Ke-Xin; Shen, Xi-Hui; Jiang, Chen-Ying; Liu, Shuang-Jiang*.Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum.Applied Microbiology and Biotechnology, 2008, 78(1): 75-83.

[102]Banga, Simran; Gao, Ping; Shen, Xihui; Fiscus, Valena; Zong, Wei-Xing; Chen, Lingling; Luo, Zhao-Qing*.Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(12): 5121-5126.

[103]Chaudhry, Muhammad Tausif; Huang, Yan; Shen, Xi-Hui; Poetsch, Ansgar; Jiang, Cheng-Ying; Liu, Shuang-Jiang*.Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum.Microbiology-SGM, 2007, 153: 857-865.

[104]Feng, Jie; Che, Yongsheng; Milse, Johanna; Yin, Ya-Jie; Liu, Lei; Rückert, Christian; Shen, Xi-Hui; Qi, Su-Wei; Kalinowski, Jörn; Liu, Shuang-Jiang*.The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum.Journal of Biological Chemistry, 2006, 281(16): 10778-10785.

[105]Huang, Yan; Zhao, Ke-Xin; Shen, Xi-Hui; Chaudhry Muhammad Tausif; Jiang, Cheng-Ying; Liu, Shuang-Jiang*.Genetic characterization of the resorcinol cataboiic pathway in Corynebacterium glutamicum.Applied and Environmental Microbiology, 2006, 72(11): 7238-7245.

[106]Xihui Shen, Shuang-Jiang Liu*. Molecular basis of the protocatechuate branch of the β-ketoadipate pathway for aromatic degradation in Corynebacterium glutamicum. Science in China 2005, 48: 241-249.

[107]Xi-Hui Shen; Yan Huang; Shuang-Jiang Liu*.Genomic analysis and identification of catabolic pathways for aromatic compounds in Corynebacterium glutamicum.Microbes and Environments, 2005, 20(3): 160-167.

[108]Shen, Xi-Hui; Jiang, Cheng-Ying; Huang, Yan; Liu, Zhi-Pei; Liu, Shuang-Jiang*.Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum.Applied and Environmental Microbiology, 2005, 71(7): 3442-3452.

[109]Xihui Shen, Zhipei Liu, and Shuang-Jiang Liu*. Functional identification of the gene locus (ncg12319) and characterization of catechol 1,2-dioxygenase in Corynebacterium glutamicum. Biotechnology Letters 2004, 26:575-580. 

發表中文期刊論文

[1]李夢園, 王逍, 楊亞東, 湯晶晶, 謝臻, 徐磊, 沈錫輝, 王瑤*. 鼠傷寒沙門氏菌sopF基因缺失突變體的構建及調節宿主自噬功能研究[J]. 動物醫學進展, 2023, 44 (03): 1-7.

[2]李夢園, 王逍, 沈錫輝, 王瑤, 徐磊*. STING介導的天然免疫反應在細菌感染中作用研究進展[J]. 動物醫學進展, 2023, 44 (02): 84-88.

[3]趙文瑾, 尚道涵, 謝來工, 沈錫輝, 張磊*. 銅綠假單胞菌環二鳥苷酸代謝及其調控生物膜形成研究進展[J]. 中國病原生物學雜志, 2022, 17 (12): 1468-1474.

[4]于宗蘭, 朱凱祥, 張辰, 潘大敏, 楊彥濤, 沈錫輝. 銅綠假單胞菌PA14 H3-T6SS的調控功能研究[J]. 西北農林科技大學學報(自然科學版), 2023, 51 (06): 123-130.

[5]尹雁玲, 蔡然, 張功良, 楊彥濤, 劉興宇, 沈錫輝*. 植物內生菌增強植物對生物脅迫抗性的研究進展[J]. 廣西植物, 2023, 43 (02): 212-220.

[6]謝臻, 湯晶晶, 沈錫輝, 郭抗抗*, 徐磊*. 細菌外膜囊泡調節宿主天然免疫反應機制研究進展[J]. 動物醫學進展, 2022, 43 (05): 78-83.

[7]謝曉榮, 尚道涵, 沈錫輝, 張磊*. AI-2通過調節c-di-GMP代謝酶DosC影響類志賀鄰單胞菌生物膜形成及運動性[J]. 微生物學報, 2022, 62 (07): 2808-2823.

[8]楊昶杏, 孟凡能*, 張文越, 楊培鈺, 王丹丹, 劉興宇, 王瑤*, 沈錫輝. 假結核耶爾森氏菌中Phd-Doc毒素-抗毒素系統的功能鑒定[J]. 微生物學通報, 2021, 48 (10): 3554-3568.

[9]Meiru Si, Yao Wang, Bing Zhang, Chao Zhao, Yiwen Kang, Haonan Bai, Dawei Wei, Lingfang Zhu, Lei Zhang, Tao G.Dong, 沈錫輝. 細菌六型分泌系統利用一個受氧化還原調節的雙功能血紅素轉運蛋白獲取鋅[J]. 科學新聞, 2018, (04): 137.

[10]楊志方, 肖瀟, 司美茹, 成娟麗, 沈錫輝, 王瑤. 谷氨酸棒桿菌中苯酚羥化酶的鑒定及功能研究[J]. 西北農林科技大學學報(自然科學版), 2015, 43 (12): 191-198.

[11]高奮; 王鐵濤; 朱玲芳; 沈錫輝*.假結核耶爾森氏菌VI型分泌系統T6SS-2的抑菌功能研究.中國科技論文在線, 2014, 0(0): 1-6.  

[12]張磊, 沈錫輝. 改革微生物學實驗教學模式 培養創新型人才[J]. 教育教學論壇, 2012, (38): 25-26.

[13]沈錫輝,劉雙江*. 谷氨酸棒桿菌中芳香化合物降解的β-酮己二酸途徑中原兒茶酸分支關鍵酶的鑒定[J]. 中國科學C輯:生命科學, 2004, 34(06): 547-554.

[14]沈錫輝,劉志培,王保軍,劉雙江*. 苯酚降解菌紅球菌PNAN5菌株(Rhodococcussp.strain PNAN5)的分離鑒定、降解特性及其開環雙加氧酶性質研究[J]. 環境科學學報, 2004,34 (03): 482-486.

[15]吳建峰,沈錫輝,周宇光,劉雙江. 一株降解對氯硝基苯的Comamonas sp.CNB1的分離鑒定及其降解特性[J]. 微生物學報, 2004, (01): 8-12. 

[16]沈錫輝,王開梅,張志剛,陳在佴,鎮達. 用離子交換吸附法回收Bt發酵液上清中的增效物質[J]. 中國生物防治, 2004, (01): 34-37. 

[17]陳在佴,吳繼星,張志剛,王海林,廖先清,沈錫輝. 我國蘇云金桿菌液體深層發酵研究十年進展(1990-2000)[J]. 中國生物防治, 2002, (01): 33-35.

[18]王瑤,林木蘭,沈錫輝,柳晟. 農桿菌介導的木本植物遺傳轉化[J]. 生物技術通報, 1999, (06): 23-27.

[19]羅淑平,李發民,沈錫輝. 陜西省玉米雜交種種質基礎分析[J]. 西北農林科技大學學報(自然科學版), 1995, (S2): 46-51.  

[20]郭呈昊; 林金水; 王瑤; 沈錫輝*.細菌VI型分泌系統結構與功能的研究進展中國科技論文在線.

發表會議論文

[1]沈錫輝.細菌VI型分泌系統的抗環境脅迫功能研究.第十八次全國環境微生物學學術研討會, 中國,江蘇省,鎮江市, 2015-11-21至2015-11-24.

[2]沈錫輝.細菌VI型分泌系統與環境脅迫.中國遺傳學會大會，微生物遺傳學與環境分會場, 中國,云南省,昆明市, 2015-08-14至2015-08-18.

[3]沈錫輝.假結核耶爾森氏菌VI型分泌系統的新功能.病原細菌的化學生物學研討會, 中國,貴州省,貴陽市, 2015-04-18至2015-04-20.

[4]Gong, Jian; Shen, Xihui; Yang, Rongge.RHESUS MONKEY TRIM5A REPRESSES HIV-1 LTR PROMOTER ACTIVITY VIA NEGATIVELY REGULATING TLR-MEDIATED NF-KB PATHWAY

[5]Ziqiang, Du1, 2*; Yudan, Shen3; Jian, Wang1; Xihui, Shen1, 4.A remote sensing-based integrated approach for monitoring grassland degradation: Case study on the representative grassland near the middle and upper reaches of Heihe River basin, western China.Remote Sensing and Modeling of Ecosystems for Sustainability IV, 2007-08-28 to 2007-08-29.

[6]劉雙江,沈錫輝,黃燕,亓蘇偉,M．Tausif Chaudhry,馮婕... & 姜成英. (2006). 谷氨酸棒桿菌(Corynebacterium glutamicum)降解芳香化合物的功能基因組學. (eds.) 首屆全國微生物基因組學學術研討會會程與論文摘要集 (pp.31). 

[7]沈錫輝; 劉雙江.谷氨酸棒桿菌(Corynebacterium glutamicum)降解芳香化合物的功能基因組學分析.第七次全國環境微生物學術研討會, 中國,上海市, 2004-10-23.

 

榮譽獎勵：

1、西北農林科技大學“青年英才培養計劃”首屆入選者。

2、2017年獲批國家杰出青年科學基金項目。

 農業與環境微生物團隊

團隊介紹 

西北農林科技大學生命學院“農業與環境微生物”研究團隊依托旱區作物逆境生物學國家重點實驗室，瞄準微生物領域國際科技前沿，緊密圍繞國家戰略需求和區域發展需要，深入開展面向西部旱區農業生產實際的基礎和應用基礎研究，形成了一支學術氛圍濃郁，規章制度完善，年齡梯度和知識結構合理的科研生力軍。團隊現有教授2人，副教授1人，講師4人，博士后、研究生共40余人。 

團隊帶頭人沈錫輝教授為國家杰出青年科學基金獲得者，入選國家“萬人計劃”、科技部中青年科技創新領軍人才推進計劃和陜西省特支計劃。 

沈錫輝教授在細菌六型分泌系統的離子轉運與抗環境脅迫新功能、植物內共生微生物促作物抗旱抗逆機制、微生物-環境-宿主相互作用機制研究等方面取得了比較突出的進展，以通訊作者在Nature Communications、PNAS、Cell Reports等國際著名期刊發表SCI論文50余篇。研究成果“微生物主動運輸新機制”被中國微生物學會推薦為2017年度“中國生命科學領域十大進展”唯一參評項目。在2017年國家杰出青年基金評選中，作為國家基金委生命科學部唯一來自西部的答辯人并成功入選，也是我校自2012年以來唯一的國家杰青入選者。 

團隊事跡 

團隊在研究生培養過程中，不僅注重對研究生科學精神和科研能力的培養，還注意將思想政治教育融入課程和科研活動，潛移默化地培養研究生的愛國主義情懷，教育引導學生“誠實做人，誠信做事”，努力營造“追求卓越、協同創新、踏實勤奮、勇于奉獻”的團隊文化，團隊成員團結友愛，互幫互助，通力合作。 

團隊一貫重視對青年人才的培養，盡全力通過多種方式招募人才組建團隊，精心為年輕人制定發展規劃，設計研究計劃，提供良好的事業發展空間和機會，同時在生活中給予青年人無微不至的關懷，通過事業、感情和手把手的傳幫帶聚集了一批有潛力的青年人才共同為西部農業微生物和綠色可持續發展的宏大目標而奮斗。 

團隊還積極為本科生提供科研實踐的機會，凡有對微生物感興趣的同學參觀實驗室都熱情接待，引導感興趣的同學參與大學生科創、科研訓練和畢業論文設計等，吸引學生提前進入實驗室實踐，并在過程中悉心指導，引導學生對科研產生興趣，提升學生的探索意識和科學精神。 

優秀畢業生 

博士生司美茹以一作在PNAS，Cell Reports，Antioxidants & Redox Signaling等國際頂尖期刊發表多篇高水平SCI論文，其中一篇被Faculty of 1000推薦，被聘為曲阜師范大學生命學院副教授、碩士生導師。 

博士生林金水以一作在Nature Communications（ESI高被引論文），Frontiers in Cellular and Infection Microbiology等發表SCI論文多篇，入選陜西高校首批“青年杰出人才”計劃和陜西省 “特支計劃”區域發展人才。 

張偉鵬入選中國海洋大學“英才工程”和“優青培育計劃”，被聘為教授、博士生導師。 

博士生崔博宇和王鐵濤分別獲得陜西省第一屆和第二屆創新成果展暨創新成果洽談會一等獎。 

有多名研究生獲得國家獎學金、大北農獎學金、優秀黨員、優秀畢業生、優秀研究生等榮譽稱號。 

團隊人才 

青年教師張磊自加入團隊以來發表SCI論文20余篇（含雙一流A類文章1篇），主持國家自然科學基金2項，晉升為副教授、博士生導師。 

青年教師徐磊來校后已發表SCI論文多篇，申請到國家自然科學基金青年項目、中國博士后特別資助、陜西省博士后特別資助、中國博士后面上資助（一等）和陜西省基礎科學研究項目（青年）等多項資助，累計獲批科研經費92萬元，由其負責的科研項目已取得重要進展，有望沖擊頂級期刊。 

團隊榮譽 

沈錫輝教授帶頭的農業與環境微生物團隊以立德樹人為根本，以為黨育人、為國育才為責任和使命，以豐碩的育人成效、卓越的科研業績、高效的團隊管理取得了令人矚目的成績。 

該團隊是師德高尚的優秀團隊。團隊教師言傳身教，以崇高的師德師風和精湛的業務能力教育學生影響學生，培養的研究生在各自領域建功立業，人才培養成效顯著。多名研究生在Nature、Nature Communications、PNAS等國際知名期刊上發表研究論文，多名研究生在學期間獲評國家獎學金、優秀研究生等榮譽稱號。 

該團隊是精誠團結的戰斗團隊。團隊成員有極強的組織力和凝聚力，教職工黨員占80%，研究生黨員占60%，團隊建設有明確的目標，有為實現目標制定的詳細規劃，團隊成員有干勁、有拼勁、有闖勁，共同豎起了我國西部農業微生物研究領域的一面旗幟。 

該團隊是追求卓越的先鋒團隊。團隊成員仰望星空的同時銘記腳踏實地，用一個個日月星辰的堅守和拼搏，取得了令人矚目的成績。團隊帶頭人是我校自2012年以來唯一的國家杰青入選者，團隊成員均有卓越的科研業績，團隊成員有極為可觀的發展前景和廣闊的發展空間。 

該團隊有突出的業績貢獻，團隊成員嚴謹治學、追求卓越，在微生物領域的研究達到國內一流水平，收到領域內專家的一致好評，在我國西部地區獨樹一幟。 

該團隊在立德樹人工作中取得了顯著成績。團隊培養的研究生政治素養過硬、理論基礎扎實、業務能力精湛，畢業后奮斗在各行各業，為祖國的教育、科研和“三農”事業貢獻力量。 

來源: 黨委宣傳部   2022-06-30 

 

本科、碩士就讀于西農，在中科院微生物所攻讀微生物學博士，又在美國普度大學生物科學系作博士后，最終于2010年從武漢病毒所病毒學國家重點實驗室回到母校。一路走來，沈錫輝始終在與微生物“打交道”，闖出了屬于自己的一片天地。 

“三年困難時期” 

“當時學校正在實施人才強校戰略，我又是陜西人，覺得學校微生物研究基礎很好，回來發展前景廣闊，于是就選擇回到家鄉、回到母校工作。” 

萬事開頭難。剛回來，一切都要重新開始，當時無論是經費還是人員、實驗室都比較緊張，而且前三年也沒有文章產出，壓力可想而知。當時和沈錫輝一起到校的張偉鵬碩士，暫時沒有安排住宿，為了不耽誤實驗，就在實驗室地上鋪床堅持了一個多月。 

“學校給的50萬元科研啟動經費能保障工作正常運轉，但要想保證科研工作不斷線，還要不斷申請基金等項目。”沈錫輝說，幸運的是成功申請到了基金，又得到了學校一些支持計劃、重點項目等的支持，這對當時正處于爬坡過坎階段的沈錫輝來說，每一筆經費都是雪中送炭。 

有了經費，還要有人。當時經常是招到合適的人了，對方突然說不來了，那么當年就沒有博士生了，又得等一年。這種狀況直到2017年以后才有所好轉。 

找準研究方向 

來校后，沈錫輝經過認真思考，選擇細菌六型分泌系統作為主要研究方向。細菌六型分泌系統在2006年才開始發現，沈錫輝算是進入這個領域比較早的。他告訴記者，無論是在動物腸道還是在植物根系都有很多微生物，因為營養、生長空間等有限，微生物之間也存在競爭，而且經常是你死我活。細菌六型分泌系統其實就是一種競爭的主要武器。有些細菌在腸道或根系的生存能力強，就是因為有這個比較強大的武器。所以就是想通過研究把這個武器的功能揭示出來，以后在工業、農業或者健康方面，通過合成生物學的手段來加以改造、利用。 

目前沈錫輝團隊圍繞細菌六型分泌系統主要開展的是理論研究，為將來與學校作物、園藝、動科、動醫等方面的交叉打下基礎。比如腸道里有個病原菌侵染了，沒法治療，但如果找到另外一個菌或者改造一個菌，它有更強大的競爭力，就可以把壞的細菌消滅掉。作物上基本也是這個思路。 

微生物菌群不僅有競爭，還有合作。沈錫輝研究的另外一方面，就是微生物之間存在怎樣的“對話交流”，從而達到互相的平衡和諧。“‘和談’不成就會啟動‘戰爭’，像人與人之間一樣。這種對話是否也會跨界，比如說細菌與真菌之間、甚至是細菌和它的宿主之間是如何對話的？這也是團隊現在關注的一個研究方向。”沈錫輝表示。 

打造知名團隊 

作為學校旱區作物逆境生物學與綠色生產學科群團隊之一，沈錫輝團隊有教授3名、副教授4名，講師2名，博士研究生10余名，碩士研究生30余名，還有部分本科生參與，主要圍繞微生物、分子生物學和生物化學開展工作。 

沈錫輝對團隊有著明確的目標，那就是把團隊初步打造成微生物領域國內知名團隊。按照這個目標，沈錫輝認為團隊還需要進一步完善，重點是引進生物信息學、結構生物學方面人才，從而讓團隊學科結構更加完整，競爭力更強。 

沈錫輝十分重視學科交叉。學校現有的植物保護、畜牧學兩個一流學科，與團隊微生物方向十分吻合。腸道微生物研究有助于和畜牧學學科結合，植物生防菌研究有助于揭示病原菌的防控機制，能和植物保護學科緊密結合。目前，團隊有關動物腸道微生物的研究已在PNAS、NC等期刊發表多篇文章，植物保護方面目前已和黃麗麗教授團隊展開合作。此外，和資環學院有關專家也開展了合作。“團隊只有跟學校發展方向密切結合才能發展進步。學校微生物研究實力雄厚，希望齊心協力把學校微生物學科做大做強，為學校的學科發展作出我們積極的貢獻。”沈錫輝說。 

爭取進入“國家隊” 

沈錫輝組建大團隊時間不長，通過外部引進和內部吸收，招收了不少年輕人，團隊整體比較年輕。他認為，年輕人有干勁、有闖勁，要好好愛護、培養，成為骨干力量。比如去年留在團隊的兩個年輕人都做得很好，其他幾個年輕人也都很有發展潛力，要努力把他們培養成國家級青年人才。只有把年輕人培養起來，團隊才能做大做強。 

作為團隊負責人，沈錫輝也思考謀劃著團隊未來，如何把這樣一支年輕的隊伍帶好。“基礎研究和應用研究一定要雙輪驅動。下一步我們想在合成生物學方面有所作為。因為合成生物學主要依賴于微生物，目前已上升為國家戰略，將來在農業生產應用等方面前景廣闊。”沈錫輝介紹，目前已有直接把二氧化碳合成淀粉的技術，將來是不是也可以合成油、合成更多蛋白質？學校目前參加合成生物學重點專項的團隊比較少，自己團隊也只是參加了一些課題和子課題。 

“我們希望將來能主持合成生物學方面的項目，從而把合成生物學廣泛應用于農業生產。比如在動物腸道和植物根系方面怎樣進行合成生物學改造，提高它的功能。方向選好了，我們研究的問題、開展的工作才會有科學價值，才能真正對國民經濟和農業生產作出貢獻，真正把文章寫在大地上。”沈錫輝表示。